A method of generating data output containing physiological and motion-related information includes sensing physical activity of a subject via at least one motion sensor attached to the subject, sensing physiological information from the subject via at least one photoplethysmography (PPG) sensor attached to the subject, and processing signals from the at least one motion sensor and signals from the at least one PPG sensor into a multiplexed serial data string of physiological information and motion-related information. A plurality of subject physiological parameters can be extracted from the physiological information, and a plurality of subject physical activity parameters can be extracted from the motion-related information. The serial data string is parsed out such that an application-specific interface can utilize the physiological information and motion-related information for an application that generates statistical relationships between subject physiological parameters and subject physical activity parameters in the physiological information and motion-related information.
