BRUTONS TYROSINE KINASE INHIBITOR COMBINATIONS AND USES THEREOF农业专利-农业学术服务平台

发明人:: KUO, HSU-PING,郭旭萍,郭旭萍,HSIEH, HSIN-KANG,谢欣康,謝欣康,CHANG, BETTY,张贝蒂,張貝蒂,XUE, LING,薛玲,薛玲,BALASUBRAMANIAN, SRIRAM,巴拉苏罗马尼恩司瑞雷门,巴拉蘇羅馬尼恩司瑞雷門,CHEUNG, LEO,张宏杰,張宏傑

摘要：: Disclosed herein are methods, compositions, and kits for treating a B-cell malignancy comprising administering a combination of a BTK inhibitor (e.g. ibrutinib) and a PIM inhibitor. Also disclosed herein are methods, compositions, and kits for treating a BTK-resistant B-cell malignancy comprising administering a combination of a BTK inhibitor (e.g. ibrutinib) and a PIM inhibitor.本文揭示用於治療B細胞惡性病之方法、組成物、及套組,其包括投予BTK抑制劑(例如,依魯替尼(Ibrutinib))與PIM抑制劑之組合。本文亦揭示用於治療BTK抗性B細胞惡性病之方法、組成物、及套組,其包括投予BTK抑制劑(例如,依魯替尼)與PIM抑制劑之組合。