VANSCHOOTEN, WIM,TRINKLEIN, NATHAN,FORCE-ALDRED, SHELLEY,BRUGGEMANN, MARIANNE,OSBORN, MICHAEL
申请号：
CA3034706
公开号：
CA3034706A1
申请日:
2017.08.22
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Human or chimeric heavy chain-only antibodies are provided, in the native amino acid residue at the first position of the fourth framework region (FR4) of said HCAb is substituted by a different amino acid residue that is capable of disrupting a surface-exposed hydrophobic patch comprising or associated with the native amino acid residue at that position.
