WANG, DA HYEKR,왕다혜,LEE, JI EANKR,이지언,KWON, SUN SANGKR,권순상,LEE, JUNG MINKR,이정민,HAN, JEUNG HIKR,한정희,KIM, YOUNG EUNKR,김영은
申请号:
KR1020150153436
公开号:
KR1020170051078A
申请日:
2015.11.02
申请国别(地区):
KR
年份:
2017
代理人:
摘要:
The present invention relates to a skin external application composition comprising an extract of a Glycyrrhiza uralensis and Paeonia lactiflora mixture as an active ingredient to relieve stimulation and inflammation of skin and, more specifically, to a composition capable of relieving skin stimulation due to various external toxic substances, and inhibiting inflammation by further including one or more medical herb extracts selected from Paeonia lactiflora, Angelica gigas, Rheum palmatum, Aralia continentalis, Angelica dahurica, Lycopus lucidus, Schizonepeta tenuifolia, and Phellodendron amurense in the Glycyrrhiza uralensis and Paeonia lactiflora mixture. According to an embodiment of the present invention, the skin external application composition minimizes side effects by using a natural extract detoxifies and discharges toxins by increasing expression of NQO1, which detoxifies external toxins, and GSTT1 which discharges the toxins and protects skin by increasing expression of hBD3 which is a natural immunity factor. The skin external application composition relieves the skin stimulation and the inflammation by inhibiting IL-6, IL-8, TNF-&alpha, etc. which are cytokines generated by ultraviolet rays and inhibiting yellow dust, heavy metal included in the yellow dust, and NO due to air pollution substances. According to the present invention, the skin external application composition has an excellent antioxidant effect. Therefore, the skin external application composition can be variously applied to cosmetics industry.COPYRIGHT KIPO 2017본 발명은 감초 및 작약 혼합물의 추출물을 유효성분으로 함유하는 피부 자극 및 염증 완화용 피부 외용제 조성물에 관한 것으로, 보다 구체적으로는 감초 및 작약 추출물에, 작약, 당귀, 대황, 독활, 백지, 택란, 형개, 및 황백으로부터 선택되는 어느 1종 이상의 한약재 추출물을 더 함유함으로써 외부의 다양한 독성물질로 인한 피부 자극을 완화시키고 염증 발생을 억제하는 효과를 갖는 조성물에 관한 것이다.본 발명에 따른 피부 외용제 조성물은 천연 추출물을 사용하여 부작용을 최소화할 뿐만 아니라, 외부로부터 유입된 독소를 해독하는 효소인 NQO1, 독소를 배출하는 효소인 GSTT1의 발현을 증가시킴으로써 독소를 해독 및 배출하고, 자연면역인자인 hBD3 발현을 증가시켜 피부를 보호한다. 또한, 자외선에 의해 발생하는 사이토카인인 IL-6, IL-8, TNF-α 등을 억제하