The present invention provides a non parenteral and non ocular herbal synergistic detoxifier formulation effective for blood purification, blood detoxification and in the treatment and management of disorders related to accumulation of toxins in the body having synergistic effect of its componets in specific ratio, better bioavailabilty, patient compliance in the terms of palatability, ease of administration and is formulated in a dry deUveiy form or a liquid delivery form using a controlled release vehiclein the form of Syrup, Lozenges, sub lingual tablets or chewable tablets .The present invention also provided a method of preparation of this formulation.