FLERI Melissa (US),ФЛЕРИ Мелисса (US),GENDRON Roland (US),ГЕНДРОН Роланд (US),KHJUZ Adam D. (US),ХЬЮЗ Адам Д. (US)
申请号：
RU2013142258/04
公开号：
RU0002604522C2
申请日:
2012.02.16
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention relates to a compound of formula I, where R1 denotes -OR7； R2a is selected from -CH2OH, -CH2OP(O)(OH)2 and -CH2OC(O)CH(R37)NH2； or R2a together with R7 forms -CH2O-CR18R19-； R2b is selected from H and -CH3； Z denotes -CH-； X is selected from a pyrazole, imidazole, triazole, benzotriazole, oxazole, isoxazole, pyrimidine, pyridazine, benzimidazole, pyran and triazolo[4,5-b]pyridine； R3 is absent or is selected from H； halogen； -C0-5alkylene-OH； -C-1-6alkyl； -C(O)R20； -C0-1alkylene-COOR21； -C(O)NR22R23； =O； phenyl, optionally substituted with one or two groups, independently selected from halogen； and pyridinyl； R4 is absent or is selected from H； -OH； halogen； -C1-6alkyl； -CH2OC(O)CH(R36)NH2； -CH[CH(CH3)2]-NHC(O)O-C1-6alkyl； and phenyl or benzyl； a = 0； b = 0 or an integer from 1 to 3； each R6 is independently selected from halogen； R7 is selected from H, -C1-8alkyl,-C1-3alkylene-C6-10aryl, [(CH2)2O]1-3CH3, -C1-6alkylene-OC(O)R10, -C1-6alkylene-NR12R13, -C1-6alkylene-C(O)R31, -C0-6alkylenemorpholinyl, -C1-6alkylene-SO2-C1-6alkyl； structural formulae (a1), (a2), (a3) and (a4)； R10 is selected from -C1-6alkyl, -O-C1-6alkyl, -C3-7cycloalkyl, -O-C3-7cycloalkyl and -CH[CH(CH3)2]-NH2； and R12 and R13 are independently selected from H, -C1-6alkyl and benzyl, or R12 and R13 together form -(CH2)5- or -(CH2)2O(CH2)2-； R31 is selected from -O-benzyl and -NR12R13； and R32 denotes -C1-6alkyl； R18 and19 are independently selected from H and -C1-6alkyl； R20 is selected from H and -C1-6alkyl； R21 denotes H； R22 and R23 are independently selected from H, -C1-6alkyl, -(CH2)2OCH3 and -C0-1alkylene-C3-7cycloalkyl； or R22 and R23 together form a saturated -C3-5heterocycle, selected from azetidine or pyrrolidine； and optionally containing an oxygen atom in ring； R36 is selected from H, -CH(CH3)2, phenyl and benzyl； and R37 is selected from H and -CH(CH3)2； and where methylene linker on biphenyl can be substituted with one or two -C1-6alkyl groups； or a
