patent summary: "triazole carboxamide derivatives". The invention relates to compounds of formula (I) wherein R1 is phenyl or pyridinyl optionally substituted by halogen, lower alkyl, lower alkoxy, halogen substituted lower alkyl and halogen substituted lower alkoxy； x1 is -n = or ch； x2 is cr2 or = n-； x3 is -n = or ch； provided that only two of x1, x2 or x3 are nitrogen； wherein is a triazole group selected from or； R2 is hydrogen or lower alkyl: z is a bond, -o- or -ch2-； or to pharmaceutically suitable acid addition salts thereof. It has now been found that the compounds of formula I have good affinity for the trait of amine associated receptors (taars), especially for taar1. The compounds may be used for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder (ADHD), stress-related disorders, psychotic disorders such as schizophrenia, neurological disorders such as parkinson's disease, neurodegenerative disorders. such as alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, energy consumption and assimilation disorders, body temperature homeostasis disorders and malfunction, sleep disorders and circadian rhythm； and cardiovascular disorders. 1/1resumo patente de invenção: "derivados de carboxamida de triazol". a invenção se refere a compostos de fórmula (i), em que r1 é fenila ou piridinila, opcionalmente substituída por halogênio, alquila inferior, alcóxi inferior, alquila inferior substituída por halogênio e alcóxi inferior substituído por halogênio； x1 é -n= ou ch； x2 é cr2 ou =n-； x3 é -n= ou ch； com a condição de que apenas dois de x1, x2 ou x3 sejam nitrogênio； em que é um grupo triazol, selecionado de , ou ； r2 é hidrogênio ou alquila inferior: z é uma ligação, -o- ou -ch2-； ou a sais de adição de ácido farmaceuticamente adequados do mesmo. constatou-se atualmente que os compostos
