ANDERS BJOERK,STIG JOENSSON,TOMAS FEX,GUNNAR HEDLUND
申请号：
BR9912109
公开号：
BR9912109B1
申请日:
1999.07.14
申请国别(地区):
BR
年份:
2012
代理人:
摘要：
The invention is related to compounds of general formula (I), wherein R is methyl, ethyl, n-propyl, iso-propyl, n-butyl or allyl； R' is methyl, methoxy, fluoro, chloro, bromo, trifluoromethyl, or OCHxFy, wherein x = O - 2, y = 1 - 3 with the proviso that x + y = 3； R'' is hydrogen, fluoro or chloro； with the proviso that R'' is fluoro or chloro only when R' is fluoro； R4 is hydrogen or pharmaceutically acceptable inorganic or organic cations； R5 is ethyl, n-propyl, iso-propyl, methoxy, ethoxy, chloro, bromo, trifluoromethyl, OCHxFy, or OCH2CHxFy wherein x = 0 - 2, y = 1 - 3 with the proviso that x + y = 3； R6 is hydrogen； or R5, and R6 taken together are methylenedioxy； and any tautomer thereof. The invention also relates to pharmaceutical compositions containing a compound of general formula (I) together with a pharmaceutically acceptable carrier. Included are also processes for the preparation of the compounds of formula (I), as well as methods for the treatment of mammals suffering from diseases resulting from autoimmunity and pathological inflammation by administering of a compound having formula (I) to said mammal.
