BJOERK, ANDERS,JOENSSON, STIG,FEX, TOMAS,HEDLUND, GUNNAR
申请号：
HU0103224
公开号：
HU229427B1
申请日:
1999.07.14
申请国别(地区):
HU
年份:
2013
代理人:
摘要：
The invention is related to compounds of general formula (I), wherein R is methyl, ethyl, n-propyl, iso-propyl, n-butyl or allyl； R' is methyl, methoxy, fluoro, chloro, bromo, trifluoromethyl, or OCHxFy, wherein x = O - 2, y = 1 - 3 with the proviso that x + y = 3； R'' is hydrogen, fluoro or chloro； with the proviso that R'' is fluoro or chloro only when R' is fluoro； R4 is hydrogen or pharmaceutically acceptable inorganic or organic cations； R5 is ethyl, n-propyl, iso-propyl, methoxy, ethoxy, chloro, bromo, trifluoromethyl, OCHxFy, or OCH2CHxFy wherein x = 0 - 2, y = 1 - 3 with the proviso that x + y = 3； R6 is hydrogen； or R5, and R6 taken together are methylenedioxy； and any tautomer thereof. The invention also relates to pharmaceutical compositions containing a compound of general formula (I) together with a pharmaceutically acceptable carrier. Included are also processes for the preparation of the compounds of formula (I), as well as methods for the treatment of mammals suffering from diseases resulting from autoimmunity and pathological inflammation by administering of a compound having formula (I) to said mammal.
