Commissariat à lEnergie Atomique et aux Energies Alternatives
发明人:
NAVARRO Y GARCIA, Fabrice,BRUNIAUX, Jonathan,GIDROL, Xavier,SULPICE, Eric,TEXIER-NOGUES, Isabelle
申请号：
ES13748032
公开号：
ES2662023T3
申请日:
2013.08.12
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
Formulation in the form of nanoemulsi\u00f3n, comprising a continuous aqueous phase and a dispersed Phase, which includes: - at least 5% Lipid molar anf\u00edfilo,- from 15 to 70 MOLE% of a cationic Surfactant, at least comprising: at least a lipophilic Group selected from: - a group R or R - (c = o) -,Where R represents a linear Hydrocarbon Chain comprising from 11 to 23 carbon AtomsAn ester or amide of fatty acids comprising 12 to 24 carbon Atoms and phosphatidylethanolamine, and a Poly (Propylene Oxide)And at least a hydroxyl group which comprises at least one group selected from cationic: a linear or branched alkyl group which comprises 1 to 12 carbon Atoms and \/ or Interrupted.At least one group formed by cationic Polymer and Hydrophilic Group - a group which comprises at least a cationicAnd from 10% to 55% of cosurfactant molar which comprises at least a Chain of Poly (ethylene oxide) comprising at least 25 units of ethylene oxide, Lipid - a solubilizer,Optionally a Lipid fus\u00f3geno, optionally an oil, optionally an Imaging Agent, and optionally a lipophilic Therapeutic Agent.The percentage of Lipid molar anf\u00edfilo,Cationic Surfactant and cosurfactant is compared with the set (anf\u00edfilo cationic Lipid \/ Surfactant \/ cosurfactant \/ Lipid fus\u00f3geno optional)And where the molar ratio of the set (Lipid Solvent \/ Oil \/ Imaging Agent \/ Optional Optional Optional lipophilic Therapeutic Agent) with respect to the dispersed phase is from 10 to 80%.Formulación en forma de nanoemulsión, que comprende una fase acuosa continua y al menos una fase dispersada, y que comprende: - al menos un 5% molar de lípido anfífilo, - del 15 al 70% molar de al menos un tensioactivo catiónico que comprende: - al menos un grupo lipófilo seleccionado entre: - un grupo R o R-(C>=O)-, donde R representa una cadena hidrocarbonada lineal que comprende de 11 a 23 átomos de carbono, - un éster o una amida de ácidos grasos que comprende de 12 a 24 átomos de carbono y fosfatidi
