KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION;NISSAN CHEMICAL CORPORATION
发明人:
ONO, FUMIYASU,小野文靖,GOTO, MASAHIRO,後藤雅宏
申请号：
TW107126858
公开号：
TW201919583A
申请日:
2018.08.02
申请国别(地区):
TW
年份:
2019
代理人:
摘要：
The purpose of the present invention is to satisfactorily dissolve a water-soluble active ingredient in a percutaneous-absorption control agent under mild conditions in a short time. The present invention relates to: a preparation method for a solution containing a water-soluble active ingredient and a percutaneous-absorption control agent, the method comprising a step in which the water-soluble active ingredient is dissolved in a short-chain alcohol to obtain a short-chain-alcohol solution (step 1), a step in which the percutaneous-absorption control agent is added to the short-chain-alcohol solution obtained in step 1 to obtain a liquid mixture (step 2), and a step in which the short-chain alcohol is removed from the liquid mixture obtained in step 2 (step 3)； a percutaneous absorption composition which comprises a lipid-soluble medium and the solution obtained by said preparation method, which comprises a water-soluble active ingredient and a percutaneous-absorption control agent； and a method for controlling the release of the water-soluble active ingredient in the skin, the method including the aforementioned steps.本發明係以使水溶性有效成分在緩和的條件下且短時間內達成對經皮吸收控制劑的良好溶解性為目的。本發明係有關於：一種調製方法，其為含有水溶性有效成分及經皮吸收控制劑之溶液的調製方法，其係包含：(步驟1)使前述水溶性有效成分溶解於短鏈醇而得到短鏈醇溶液之步驟；(步驟2)對步驟1中所得之短鏈醇溶液添加前述經皮吸收控制劑，而得到混合液之步驟；(步驟3)由步驟2中所得之混合液中去除前述短鏈醇之步驟；一種經皮吸收組成物，其係含有：以前述調製方法所得之含有水溶性有效成分及經皮吸收控制劑之溶液以及脂溶性介質；以及一種方法，其係包含前述步驟，且控制水溶性有效成分在皮膚中的釋出。
