The present disclosure relates to hAPRIL. It relates to an APRIL binding antibody that binds to the same human APRIL epitope as an antibody having an antigen binding site of 01A. The antibodies of the present disclosure comprise selected specifics of the framework sequences of the VH and VL domains, and hAPRIL. Has unexpected features compared to 01A. The present disclosure further relates to compositions comprising the antibodies of the present invention, as well as medical and diagnostic uses of the antibodies and compositions. [Selection figure] None本開示は、hAPRIL.01Aの抗原結合部位を有する抗体と同じヒトAPRILエピトープに結合するAPRIL結合抗体に関する。本開示の抗体は、VHおよびVLドメインのフレームワーク配列の選択された特定のものを含み、かつhAPRIL.01Aに比較して予想外の特色を有する。本開示はさらに、本発明の抗体を含む組成物、ならびに該抗体および組成物の医学的および診断的使用に関する。【選択図】なし