Schuch, Raymond,Nowinski, Robert C.,Wittekind, Michael,Lee, Han,Schneider, Brent
申请号：
AU2020233683
公开号：
AU2020233683A1
申请日:
2020.09.16
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
#$%^&*AU2020233683A120201008.pdf#####ABSTRACT The present invention provides various methods, including, methods of killing Staphylococcus and/or Streptococcus bacteria and inhibiting antibiotic-resistant Staphylococcus and/or Streptococcus bacteria comprising: contacting the bacteria with an altered lytic enzyme in combination with one or more antibiotic(s), wherein the altered lytic enzyme is effective to kill Staphylococcus and/or Streptococcus bacteria, wherein the altered lytic enzyme comprises a PlySs2 binding domain comprising SEQ ID NO: 4 or a variant thereof having at least 80% identity to the amino acid of SEQ ID NO: 4 and effective to bind the one or more of Staphylococcus and Streptococcus bacteria and a catalytic domain. Other methods are also provided for reducing the development of antibiotic resistance, enhancing the effectiveness of a Gram-positive antibiotic, potentiating antibiotic activity in biological fluids having surfactantlike activity, and inhibiting Gram-positive bacteria.
