The Brigham and Women's Hospital, Inc.;Beth Israel Deaconess Medical Center, Inc.
发明人:
Gerald B. Pier,Casie Anne Kelly-Quintos,Lisa Cavacini,Marshall R. Posner
申请号：
US15270461
公开号：
US10017563B2
申请日:
2016.09.20
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to poly-N-acetyl glucosamine (PNAG), such as Staphylococcal PNAG, in acetylated, partially acetylated and/or fully deacetylated form. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of infections by bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Some antibodies of the invention enhance opsonophagocytic killing and in vivo protection against bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.
