The present invention refers to a non-shivering cryothermogenesis method for locally reducing adipose tissue of a subject's body, comprising: (a) applying at least one applicator of a cooling mean to the subject's skin; (b) applying at least one additional applicator of said cooling mean to local region wherein adipose tissue reduction is desired; (c) said applicator maintaining skin superficial temperature between 4°C and 12°C; (d) applying said applicators for a total period of time comprised between 20 and 60 min;