The present disclosure refers to a non-shivering cryothermogenesis method for locally reducing adipose tissue of a subject's body, including: (a) applying at least one applicator to the subject's skin； (b) applying at least one additional applicator to a local region wherein adipose tissue reduction is desired； (c) the applicator maintaining skin superficial temperature between 4° C. and 12° C.； and (d) applying the applicators for a total period of time between 20 and 60 min.
