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COMPOSITIONS AND METHODS FOR TREATING CANCER WITH A COMBINATION OF PROGRAMMED DEATH RECEPTOR (PD-1) ANTIBODIES AND A CXCR2 ANTAGONIST
专利权人:
Merck Sharp &; Dohme Corp.
发明人:
Elaine M Pinheiro,Michael Rosenzweig,Robert A. Kastelein,David R. Kaufman,Deborah A. Law
申请号:
US16649756
公开号:
US20200276153A1
申请日:
2018.09.24
申请国别(地区):
US
年份:
2020
代理人:
摘要:
The present invention relates to methods of treating a cell proliferation disorder (e.g., cancer) comprising administering: (a) a compound having the Formula (I), wherein R1 or R2 are as herein defined, or a pharmaceutically acceptable salt thereof; and (b) an anti-human PD-1 antibody or antigen binding fragment thereof to a human patient in need thereof. Also disclosed are therapeutic combinations and kits containing such agents for the treatment of cancers.
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