CORTISTATIN ANALOGUES AND SYNTHESES AND USES THEREOF

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专利权人:

President and Fellows of Harvard College

发明人:

SHAIR, Matthew, D.,PELISH, Henry, Efrem

申请号：

EP16818816

公开号：

EP3316889A4

申请日:

2016.06.30

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

Compounds of Formula (Α), (Β), (C), (D), (Ε), (A"), (B"), (C"), (D"), (E"), (G1), and (G2) are useful as therapeutics for treating a wide variety of conditions in a host such as a human, e.g., including but not limited to, conditions associated with angiogenesis and/or which are mediated by CDK8 and/or CDK19 kinase activity. Also provided are methods of modulating the β-catenin pathway, methods of modulating STAT1 activity, methods of modulating the TGFβ/BMP pathway, methods of modulating HIF-1-alpha activity in a cell, and methods of increasing BIM expression to induce apoptosis, using an effective amount of a compound of Formula (Α), (Β), (C), (D), (Ε), (A"), (B"), (C"), (D"), (E"), (G1), or (G2).

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/