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CORTISTATIN ANALOGUES AND SYNTHESES AND USES THEREOF
专利权人:
发明人:
申请号:
EP16818816.7
公开号:
EP3316889A1
申请日:
2016.06.30
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
Compounds of Formula (A′), (B′), (C′), (D′), (E′), (A″), (B″), (C″), (D″), (E″), (G1), and (G2) are useful as therapeutics for treating a wide variety of conditions in a host such as a human, e.g., including but not limited to, conditions associated with angiogenesis and/or which are mediated by CDK8 and/or CDK19 kinase activity. Also provided are methods of modulating the β-catenin pathway, methods of modulating STAT1 activity, methods of modulating the TGFβ/BMP pathway, methods of modulating HIF-1-alpha activity in a cell, and methods of increasing BIM expression to induce apoptosis, using an effective amount of a compound of Formula (A′), (B′), (C′), (D′), (E′), (A″), (B″), (C″), (D″), (E″), (G1), or (G2).
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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