The invention relates to a device (1) for the directed application of a substance (X) in a hollow space (200), such as a hollow organ, of a body cavity, in particular a therapeutic pneumoperitoneum, comprising:a trocar system with a trocar sleeve (45), said trocar system (40) having a gas connection (43) to which an insufflation gas-supply line (81) can be connected, anda nozzle system (20), which in its interior forms a lumen (26), with a proximal end (21) and a distal end (22), wherein the nozzle system (20) has a needle nozzle (30) fixed at the distal end (22) with the lumen (26) and is guided by the trocar sleeve (45).