COMBINAISONS D'INHIBITEURS DE IKK?/TBK1 AVEC DES AGONISTES BETA-ADRENERGIQUES OU DES ACTIVATEURS DE SYSTEME NERVEUX SYMPATHIQUE

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专利权人:

THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人:

SALTIEL, ALAN R.

申请号：

CA2938126

公开号：

CA2938126A1

申请日:

2014.02.07

申请国别(地区):

CA

年份:

2015

代理人:

摘要：

Provided herein are methods of treating obesity and obesity-related conditions comprising the administration of combinations of IKKe/TBK1 inhibitors with beta adrenergic agonists or sympathetic nervous system activators, and pharmaceutical compositions comprising such combinations. Obesity generates a state of chronic, low-grade inflammation in liver and adipose tissue accompanied by macrophage infiltration and the local secretion of inflammatory cytokines and chemokines that attenuate insulin action.

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