COMBINATIONS OF IKK /TBK1 INHIBITORS WITH BETA ADRENERGIC AGONISTS OR SYMPATHETIC NERVOUS SYSTEM ACTIVATORS

• 收藏
• 分享

专利权人:

The Regents of The University of Michigan

发明人:

SALTIEL, Alan R.

申请号：

EP14881460

公开号：

EP3102206A4

申请日:

2014.02.07

申请国别(地区):

EP

年份:

2017

代理人:

摘要：

Provided herein are methods of treating obesity and obesity-related conditions comprising the administration of combinations of IKKε/TBK1 inhibitors with beta adrenergic agonists or sympathetic nervous system activators, and pharmaceutical compositions comprising such combinations. Obesity generates a state of chronic, low-grade inflammation in liver and adipose tissue accompanied by macrophage infiltration and the local secretion of inflammatory cytokines and chemokines that attenuate insulin action.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/