This invention provides a controlled dosage form-dispensing device, comprising a multi-chamber, bulk medicine storage and distribution unit, wherein said unit is provided with a plurality of individual dosage form-containing storage chambers with respective delivery ports； and a personal medication dispenser comprising a fixed dosage form extracting station comprising a dosage form receiving and extracting mechanism； wherein the medication dispenser is provided with a controller which moves the bulk medicine storage and distribution unit sequentially bringing a respective delivery port of a predetermined chamber into register with the fixed dosage form extracting station such that the dosage form receiving and extracting mechanism extracts and receives only one dosage form at a time. The dispensing device is further provided with at least one portable dosage form-dispensing cassette having a plurality of compartments and a first delivery controller for delivery of a predetermined dosage form from a predetermined compartment of the portable dosage form-dispensing cassette, the at least one portable cassette being releasably attachable to a personal medication dispenser； and a second delivery controller for the controlled delivery of predetermined dosage forms from the multi-chamber, bulk medicine storage and distribution unit to the portable dosage form-dispensing cassette via a conduit in the personal medication dispenser.
