The disclosure passes through method that the nucleic acid molecules that the inhibition that the mediated rnai of target code is led is related to control prevention and treatment disease pest are used with it and copies non-coding sequence, including coleopteran and/or hemipteran pest in prevention and treatment disease pest. The disclosure is also related to indicating that nucleic acid molecules can be used for method and obtained thereby plant cell and the plant of the genetically modified plants of control of insect pests for manufacturing.
