FERREIRA DE SA, Gonçalo Fernando,DE SERPA SOARES, Carlos Alberto Lourenço,DA SILVA ARNAUT MOREIRA, Luís Guilherme
申请号：
ES12723274
公开号：
ES2564365T3
申请日:
2012.04.19
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
Device for converting the energy of a laser pulse (1) emitted by a pulsed laser source (2) into a high-speed and broad-band acoustic transient, especially capable of increasing the administration of at least one compound in a formulation suitable pharmacological (A) in an object biological barrier or through it (B), including skin or soft tissue, characterized in that: said laser pulse (1) has an optical power density in the range between 0.1 and 40 MW / cm2, preferably between 10 and 10 MW / cm2, and the device is composed of: - a thin layer (4) of a conversion material including at least one molecular system, in which the molecular system absorbs at least part of the energy generated by said laser pulse (1) and generate a high-speed and broad-band acoustic transient in said conversion material, by means of a thermoelastic expansion and / or expansion of its structural volume and / or a photocomposition； - a structural and / or joint element (6) placed to keep said thin layer (4) of a conversion material and preferably also a window element (3) and a support element (5) in contact, guaranteeing this way an acoustic coupling between the three parts； - said pulsed laser source (2) arranged to substantially illuminate said thin layer (4) of the conversion material with said laser pulse (1) in which said laser pulse (1) has a wavelength that is substantially absorbed by said thin layer (4) of a conversion material.Dispositivo para la conversion de la energia de un pulso de laser (1) emitida por una fuente de laser pulsado (2) en un transitorio acustico de banda ancha y alto impulso, especialmente capaz de aumentar la administracion de al menos un compuesto en una formulacion farmacologica adecuada (A) en una barrera biologica objeto o a traves de la misma (B), incluyendo piel o tejido suave, caracterizado porque: dicho pulso de laser (1) posee una densidad de potencia optica en el rango entre 0,1 y 40 MW/cm2, preferiblemente entre l y 10 MW/cm2, y el dispositivo se com
