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INHIBITEURS DU CANAL POTASSIQUE MÉDULLAIRE EXTERNE RÉNAL
专利权人:
Merck Sharp & Dohme Corp.
发明人:
申请号:
EP12845426.1
公开号:
EP2773206B1
申请日:
2012.10.25
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
This invention relates to compounds of Formula I having the following general structure: and pharmaceutically acceptable salts thereof which are inhibitors of the Renal Outer Medullary Potassium (ROMK) channel (Kir1.1). The compounds are useful as diuretics and natriuretics and therefore are useful for the therapy and prophylaxis of disorders resulting from excessive salt and water retention, including cardiovascular diseases such as hypertension and chronic and acute heart failure.
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