Pepinsky, R Blake,Sah, Dinah W Y,Boriack-Sjodin, Paula Ann,Miller, Stephan S,Rossomando, Anthony
申请号：
NO20033441
公开号：
NO332150B1
申请日:
2003.08.01
申请国别(地区):
NO
年份:
2012
代理人:
摘要：
A variant neublastin polypeptide suitable for formulation of a conjugate comprising the variant neublastin polypeptide coupled to a polymer containing a polymer containing a polyalkylene glycol moiety is disclosed. The present conjugate has prolonged bioavailability and, in preferred embodiments, prolonged biological activity relative to non-modified or wild-type forms of neublastin. The conjugates of the invention are usefully employed in therapeutic as well as non-therapeutic, e.g., diagnostic, applications.
