Dinah Wen-Yee Sah,R. Blake Pepinsky,Paula Ann Boriack-Sjodin,Stephan S. Miller,Anthony Rossomando,Laura Silvian
申请号:
US12163425
公开号:
US08119114B2
申请日:
2008.06.27
申请国别(地区):
US
年份:
2012
代理人:
摘要:
A dimer comprising a mutated neublastin polypeptide coupled to a polymer is disclosed. Such dimers exhibit prolonged bioavailability and, in preferred embodiments, prolonged biological activity relative to wild-type forms of neublastin.