KIENZLE NORBERT ALEXANDER,CLARKE ADAM WILLIAM,DOYLE ANTHONY GERARD,JENNINGS PHILIP ANTHONY,POLLARD MATTHEW
申请号：
IN3366/KOLNP/2011
公开号：
IN2011KN03366A
申请日:
2011.08.09
申请国别(地区):
IN
年份:
2012
代理人:
摘要：
The present invention provides humanised antibodies and binding domains thereof with anti-tumour activity,In particular the humanised antibodies have specific binding to and direct killing of human colon tumour cells and display potent immune- mediated cytotoxic activity against human colon cancer cells in vitro using antibody-dependent cell-mediated cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC) assays and in vivo using mouse tumour models.
