KIENZLE NORBERT ALEXANDER,CLARKE ADAM WILLIAM,DOYLE ANTHONY GERARD,JENNINGS PHILIP ANTHONY,POLLARD MATTHEW
申请号：
TN2011000417
公开号：
TN2011000417A1
申请日:
2011.08.12
申请国别(地区):
TN
年份:
2013
代理人:
摘要：
The present invention provides humanised antibodies and binding domains thereof with anti-tumour activity. In particular the humanised antibodies have specific binding to and direct killing of human colon tumour cells and display potent immune-mediated cytotoxic activity against human colon cancer cells in vitro using antibody-dependent cell-mediated cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC) assays and in vivo using mouse tumour models.
