Adam W. Clarke,Anthony G. Doyle,Philip A. Jennings,Norbert Kienzle,Matthew Pollard
申请号：
US12725192
公开号：
US08470320B2
申请日:
2010.03.16
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention provides humanized antibodies and binding domains thereof with anti-tumor activity. In particular the humanized antibodies have specific binding to and direct killing of human colon tumor cells and display potent immune-mediated cytotoxic activity against human colon cancer cells in vitro using antibody-dependent cell-mediated cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC) assays and in vivo using mouse tumor models.
