A skull surgery positioning system is suitable for positioning a surgery part of skull in need of surgery and comprises a surgery device, an image capture device, and a control device. The surgery device comprises a support unit capable of being two-dimensionally displaced, and a surgery unit mounted on the support unit. The surgery unit has an indication module capable of projecting a light spot on the skull. The control device can recognize the light spot of the skull image to calculate the position parameters of the light spot relative to the surgery part and control the support unit according to the position parameters to drive the displacement of the surgery unit, making the light spot moved to the surgery part to automatically position the indication module. Automatic positioning by utilizing image recognition may reduce error due to human factors and increase surgery efficiency.一種頭骨手術定位系統,適用對一個頭骨的一個要進行手術之手術部位進行定位,並包含一個手術裝置、一個影像擷取裝置及一個控制裝置。該手術裝置包括一個可二維調移的支架單元,及一個安裝在該支架單元的手術單元,該手術單元具有一個可在該頭骨上投映出一個光點的指示模組。該控制裝置可辨識出該頭骨影像中的光點,計算出該光點相對於該手術部位的位置參數,並根據該位置參數而控制該支架單元而傳動該手術單元位移,使該光點移動至該手術部位,而將該指示模組自動定位。利用影像辨識來自動定位可以降低人為因素的失誤,並提升手術效率。10‧‧‧頭骨11‧‧‧手術部位13‧‧‧老鼠14‧‧‧平面15‧‧‧標註符號2‧‧‧手術裝置21‧‧‧支架單元211‧‧‧基座212‧‧‧移動臂213‧‧‧移動機構214‧‧‧縱向軌道215‧‧‧縱移座217‧‧‧橫向軌道218‧‧‧橫移座219‧‧‧橫向驅動器22‧‧‧手術單元220‧‧‧驅動座221‧‧‧指示模組222‧‧‧光點223‧‧‧鑽孔模組224‧‧‧注射模組225‧‧‧鑽具227‧‧‧注藥器23‧‧‧傳動機構3‧‧‧影像擷取裝置A‧‧‧箭頭L‧‧‧直立軸線
