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POLYMORPHOUS FORMS OF RIFAXIMIN, PROCESSES FOR THEIR PRODUCTION AND USE THEREOF IN THE MEDICINAL PREPARATIONS
专利权人:
ALFA WASSERMANN S.P.A.
发明人:
Giuseppe Claudio VISCOMI,Manuela CAMPANA,Donatella CONFORTINI,Maria Miriam BARBANTI,Dario BRAGA
申请号:
US14262612
公开号:
US20150073007A1
申请日:
2014.04.25
申请国别(地区):
US
年份:
2015
代理人:
摘要:
Crystalline polymorphous forms of the rifaximin (INN) antibiotic named rifaximin δ and rifaximin ε useful in the production of medicinal preparations containing rifaximin for oral and topical use and obtained by means of a crystallization process carried out by hot-dissolving the raw rifaximin in ethyl alcohol and by causing the crystallization of the product by addition of water at a determinate temperature and for a determinate period of time, followed by a drying carried out under controlled conditions until reaching a settled water content in the end product, are the object of the invention.
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中国工程科技知识中心
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