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Topical Antifungal agent
专利权人:
MEIJI SEIKA PHARMA CO.; LTD.
发明人:
OHYAMA MAKOTO,TABATA YUJI,IIDA MAIKO,KANEDA KAORI,TAKAHATA SHO
申请号:
ARP120100287
公开号:
AR084948A1
申请日:
2012.01.30
申请国别(地区):
AR
年份:
2013
代理人:
摘要:
Provides an anti trichopitona Agent comprising as active ingredient a compound having the Skeleton of 2 - (1h pyrazole - L - il) phenol.Claim 1: a compound represented by the formula (1), wherein, R1 represents a hydrogen Atom, alkyl or C1 - 6 trifluoromethyl; R2 represents a hydrogen Atom, alkyl C1 - 6 - (alkyl, halogen, COO C1 - 6) or - (CH2) represents a 3coor (1 - R Atom Hydrogen or alkyl of C1 - 6) ; R3 represents a hydrogen Atom, alkyl Amine, C1 - 6Or trifluoromethyl - or (R represents a hydrogen Atom or alkyl; R4 represents C1 - 6) a hydroxyl Group; R5 represents a hydrogen Atom, alkyl C1 - 6, a hydroxyl group or Halogen; R6 represents a C1 - 6 trifluoromethyl alkyl, halogen, Nitro, amino, Hydroxy alkyl - nrarb, C1 - 6 - conrarb, COO (C1 alkyl, - COOH, - 6)- (CH2) 1 - 3coor or ora (R represents a hydrogen Atom or alkyl C1 - 6 and ra and RB may be the same or different and represent a hydrogen Atom, alkyl or acyl C1 C1 - 6 - 6); R7 represents a hydrogen Atom, alkyl C1 - 6 - or (R represents a hydrogen Atom or alkyl C 1 - 6) or Halogen; and R8 represents a hydrogen Atom, an alkyl group C1 - 6, hydroxyl, amino or nitro,Always, when R1 is a hydrogen Atom, R is not a hydrogen Atom and exclude the compound where R1 is Tert Butyl Amine is R3, R4 and R6 is a hydroxyl Group is Methyl; or one of its Salts.Se proporciona un agente anti-Trichopitona que comprende como ingrediente activo un compuesto que tiene el esqueleto de 2-(1H-pirazol-l-il)fenol.Reivindicación 1: Un compuesto representado por la fórmula (1), en donde: R1 representa un átomo de hidrógeno, alquilo C1-6 o trifluorometilo; R2 representa un átomo de hidrógeno, alquilo C1-6, halógeno, -COO(alquilo C1-6) o -(CH2)1-3COOR (R representa un átomo de hidrógeno o alquilo C1-6); R3 representa un átomo de hidrógeno, alquilo C1-6, amino, trifluorometilo u -OR (R representa un átomo de hidrógeno o alquilo C1-6); R4 representa un grupo hidroxilo; R5 representa un átomo de hidrógeno, alquilo C1-6, un grupo hidroxilo o
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