PROBLEM TO BE SOLVED: To provide a hollow fiber membrane module having improved biocompatibility on the treatment liquid inlet side of the hollow fiber membrane module and a method for manufacturing the same. SOLUTION: A film bundle of a hollow fiber membrane having a hydrophilic group-containing polymer on the inner surface, a case covering the film bundle of the hollow fiber membrane, and a liquid to be treated provided at an end portion in the length direction of the case. A hollow fiber membrane module including an inlet side and an outlet side of the liquid to be treated, wherein the membrane bundle of the hollow fiber membrane is arranged in the length direction thereof, (a) a region including the inlet of the liquid to be treated, and (b) the center. When the region of the part and (c) the region containing the liquid outlet to be treated are divided into three equal parts and the content of the hydrophilic group-containing polymer in each region is A, B, and C, respectively, the following Hollow fiber membrane module that meets the requirements. (1) A>； B and A>； C (2) A is in the range of 20% by mass or more and 50% by mass or less (3) B and C are in the range of 15% by mass or more and 45% by mass or less [Selection diagram] None【課題】 中空糸膜モジュールの処理液入口側の生体適合性を高めた中空糸膜モジュールおよびその製造方法を提供する。【解決手段】 内表面に親水性基含有ポリマーを有する中空糸膜の膜束と、前記中空糸膜の膜束を覆うケースと、前記ケースの長さ方向の端部に設けられた被処理液入口側および被処理液出口側とを含む中空糸膜モジュールであって、 前記中空糸膜の膜束をその長さ方向に、それぞれ（ａ）被処理液入口を含む領域と、（ｂ）中央部の領域と、および（ｃ）被処理液出口を含む領域と、に３等分割し、 各領域の前記親水性基含有ポリマーの含有率をそれぞれＡ、Ｂ、およびＣとしたとき、次の要件を満たす、中空糸膜モジュール。（１）Ａ＞Ｂ、およびＡ＞Ｃである（２）Ａが２０質量％以上、５０質量％以下の範囲内である（３）ＢおよびＣが１５質量％以上、４５質量％以下の範囲内である【選択図】なし
