The present invention provides a drug eluting surgical screw and a method for manufacturing a drug eluting surgical screw. The drug eluting surgical screw may include a shaft having a threaded portion, a head having a drive recess disposed at a proximal end of the shaft, the drive recess having a reservoir region and a driver engagement region, and at least one or more drug eluting components disposed within the reservoir region of the drive recess in a manner that does not substantially impair a connection between a driver and the surgical screw when the driver is operably disposed within the driver engagement region, each of the at least one or more drug eluting components including a carrier matrix and a therapeutic agent, the therapeutic agent being at least 20 wt% of the drug eluting component prior to any implantation of the drug eluting surgical screw.本發明提供一種藥物洗提型手術用螺釘及一種用於製造藥物洗提型手術用螺釘的方法。該藥物洗提型手術用螺釘可包含一具有一螺紋部的軸桿，一具有一配置於該軸桿之近端的驅動凹部之頭部，該驅動凹部具有一貯存區及一驅動器接合區，以及至少一或更多藥物洗提組份，其係以在該驅動器可操作地配置於該驅動器接台區內時實質不損害一驅動器與該手術用螺釘之間連接的方式配置於該驅動凹部的該貯存區內，該至少一或更多藥物洗提組份中之每一者包含一載體基質與一治療劑，該治療劑在該藥物洗提型手術用螺釘的任何植入之前至少為該藥物洗提組份的20重量%。
