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HISTONE DEACETYLASE INHIBITOR, AND PREPARATION METHOD AND USE THEREOF
专利权人:
GUANGDONG ZHONGSHENG PHARMACEUTICAL CO.; LTD.
发明人:
CHEN, Lijuan,LONG, Chaofeng,CHEN, Xiaoxin,LIU, Zhuowei,YE, Haoyu,XIE, Chenshi
申请号:
EP16764254
公开号:
EP3272742A4
申请日:
2016.03.17
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
A compound represented by Formula I or pharmaceutically acceptable salt thereof. The present invention relates to a 4-arylamino quinazoline hydroxamic acid compound having a histone deacetylase inhibitory activity, preparation method of the compound, pharmaceutical composition comprising the compound, and use of the compound and the pharmaceutical composition in the preparation of a histone deacetylase inhibitor medicine. The present invention aims at acquiring, via a medicine design and a synthetic technology, a series of selective histone deacetylase inhibitors having good hypotype selectivity and favorable pharmacokinetic characteristics based on optimization of an enzyme surface recognition region and connection region of 4-arylamino quinazoline, thus reducing an effect on normal tissues or cells while improving an antineoplastic activity of the normal tissues or cells.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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