The Trustees of the University of Pennsylvania;Advaxis
发明人:
Yvonne PATERSON,Paulo Maciag
申请号：
US14163269
公开号：
US20140248304A1
申请日:
2014.02.12
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention provides recombinant proteins or peptides comprising a mutated listeriolysin O (LLO) protein or fragment thereof, comprising a substitution or internal deletion of the cholesterol-binding domain or a portion thereof, fusion proteins or peptides comprising same, nucleotide molecules encoding same, and vaccine vectors comprising or encoding same. The present invention also provides methods of utilizing recombinant proteins, peptides, nucleotide molecules, and vaccine vectors of the present invention to induce an immune response to a peptide of interest.
