非溶血性LLO融合蛋白及其用途

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专利权人:

The Trustees of The University of Pennsylvania

发明人:

PATERSON, Yvonne,MACIAG, Paulo

申请号：

HK16105309.7

公开号：

HK1217341A

申请日:

2016.05.10

申请国别(地区):

HK

年份:

2017

代理人:

摘要：

A recombinant protein comprising a listeriolysin O (LLO) protein, wherein the LLO protein comprises a mutation, or deletion of 2-11 amino acid residues within the cholesterol-binding domain (CBD) of the LLO protein, and wherein the recombinant protein exhibits a greater than 100-fold reduction in hemolytic activity relative to wild-type LLO. The recombinant protein may further comprise a heterologous peptide, such as an antigenic peptide.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/