The invention relates to a liver cancer treatment agent marking precursor and a manufacturing method thereof, and its chemical structureIn addition, its chemical structure has specific functional groups and can be dissolved in Lipiodol, or it has the characteristics of lipidol directly. Therefore, the combined radioisotopes can stay in the liver cancer tissue of patients with liver cancer through the above-mentioned specific functional groups and be applied in the body radiotherapy of liver cancer. Cure.本發明係關於一種肝癌治療劑標幟前驅物及其製造方法,其化學結構上具有配位子,能與放射性同位素之錯合物結合,且其化學結構另具有特定之官能基而可溶於利比多(Lipiodol)中,或者是進一步直接具有利比多之特性,因此可讓其所結合之放射性同位素透過前述特定之官能基而停留於肝癌患者的肝癌組織,應用於肝癌之體內放射治療。