АКАШЕ Ахмад (US),ГАОНКАР Анилкумар Ганапати (US),ЛОУРЕНС Лес (US),ЛОПЕЗ Амадо Р. (US),ХААС Джордж В. (US),СЕБЕСТА Дана (US),ВАН Янь (US)
申请号：
RU2013133411/15
公开号：
RU2013133411A
申请日:
2011.12.19
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A process for microencapsulation of the active ingredient with an enteric matrix, comprising: a) mixing a combination of water and enteric substances preferably free of organic solvents and having a pH at which the enteric substances are dissolved in water to form a solution b) mixing the solution with the hydrophobic liquid, comprising active ingredients, c) homogenizing the hydrophobic liquid and the solution to form an emulsion, and d) a certain amount of emulsion titration acid providing arr azovanie precipitate particles of the hydrophobic liquid, microencapsulated in enteric veschestve.2. A method according to claim 1, wherein the enteric material consists predominantly of shellac and caseinate natriya.3. A method according to claim 2, wherein the shellac and sodium caseinate are used in a ratio of from about 90:10 to 10: 90.4. A method according to claim 3, wherein the ratio of shellac and sodium caseinate is from about 30:70 to 70: 30.5. A method according to claim 3, wherein the ratio of shellac and sodium caseinate is from about 40:60 to 60: 40.6. A method according to any one of claims. 1-5, wherein the enteric agents are pischevymi.7. A method according to any one of claims. 1-5, further comprising applying an outer coating to precipitate microencapsulated particles by: d) mixing the enteric coating substance and a plasticizer to obtain a combination, ix) applying the combination to microencapsulated particles precipitate to obtain a precipitate microencapsulated particles pokrytiem.8. A method according to claim 7, comprising the steps of: g) utilizing a second combination of the second enteric coating substance and a plasticizer of the) coating1. Способ микроинкапсуляции активного ингредиента в энтеросолюбильной матрице, включающий:а) перемешивание комбинации воды и энтеросолюбильных веществ, преимущественно не содержащего органических растворителей и имеющего рН, при котором энтеросолюбильные вещества растворяются в воде и образуют раствор,б) смеши
