AKASHE AHMAD,GAONKAR ANILKUMAR GANAPATI,LOPEZ AMADO R.,HAAS GEORGE W.,SEBESTA DANA,WANG YAN,LAWRENCE LES
申请号：
NZ61250111
公开号：
NZ612501A
申请日:
2011.12.19
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
A method of microencapsulating an active ingredient with an enteric matrix, the method comprising: a) agitating a combination of water and enteric materials, the combination substantially free of organic solvents, at a pH so that the enteric materials are soluble in the water to form a solution, the enteric materials including shellac and sodium caseinate (casein)； b) mixing a hydrophobic liquid containing the active ingredient into the solution； c) homogenizing the hydrophobic liquid and the solution to create an emulsion； and d) acid titrating the emulsion with an amount of acid to a pH at about an isoelectric point of sodium caseinate effective to precipitate a particulate of a plurality of hydrophobic liquid drops homogenously dispersed throughout an enteric matrix of the shellac and sodium caseinate. A microencapsulated particulate composition comprising: a hydrophobic liquid； a matrix comprising an enteric material including shellac and sodium caseinate microencapsulating a plurality of drops of the hydrophobic liquid homogenously dispersed throughout the matrix； and a coating around the matrix, the coating including a combination of a plasticizer and an enteric coating material for covering the enteric matrix.
