NANOPARTICLES CONTAINED WITH POLY (ETHYL-CO-TRIMETHYLMETHYLMETHYL ETHYL ACRYLATE METHACRYLATE CHLORIDE) AND AMPHOTERICIN B AND COATED WITH HYALURONIC ACID: PROCEDURE OF GETTING, COMPOSITION AND FARMING
UNIVERSIDADE FEDERAL DE OURO PRETO;UNIVERSIDADE FEDERAL DE SÃO JOÃO DEL-REI - UFSJ
发明人:
CAROLINA MIRTES MELO,GISELE RODRIGUES DA SILVA
申请号：
BR102018067481
公开号：
BR102018067481A2
申请日:
2018.09.03
申请国别(地区):
BR
年份:
2020
代理人:
摘要：
nanoparticles consisting of eudragit rl100 and amphotericin b and coated with hyaluronic acid: process of obtaining, pharmaceutical composition and application the present invention relates to a pharmaceutical formulation composed of nanoparticles consisting of poly (ethyl methacrylate methacrylate methacrylate chloride) -co- trimethylammonioethyl), amphotericin b and coated with hyaluronic acid for the treatment of fungal infection located in the anterior and / or posterior segments of the eye, when fungal endophthalmitis is established. the aforementioned pharmaceutical formulation comprises nanoparticles incorporated with amphotericin b, an antifungal drug, poly (ethyl acrylate methacrylate chloride-methyl trimethylammonioethyl methacrylate), a copolymer with quaternary ammonium groups, which in turn have antifungal activity and hyaluronic acid, a natural mucoadhesive polysaccharide, which guarantees the adhesion of nanoparticles to the anterior segment of the eye, in addition to biocompatibility in this segment and in the posterior segment of the eye, filled by the vitreous humor, which in turn contains hyaluronic acid as the main constituent . these nanoparticles are administered via the ocular pathways to exogenous and endogenous fungal oculars resulting from endophthalmitis, in humans and animals.nanopartículas constituídas de eudragit rl100 e anfotericina b e revestidas com ácido hialurônico: processo de obtenção, composição farmacêutica e aplicação a presente invenção diz respeito a uma formulação farmacêutica composta por nanopartículas constituídas de poli (cloreto de metacrilato de acrilato de etilo-metacrilato de co-metil-co- trimetilamonioetilo), anfotericina b e revestidas com ácido hialurônico destinadas ao tratamento da infecção fúngica localizada nos segmentos anterior e/ou posterior do olho, quando estabelecida a endoftalmite fúngica. a supracitada formulação farmacêutica compreende nanopartículas incorporadas de anfotericina b, um fármaco antifún
