合肥九研医药科技开发有限公司;HEFEI JIU YAN MEDICINE TECHNOLOGY DEVELOPMENT CO., LTD; LTD;HEFEI JIU YAN MEDICINE TECHNOLOGY DEVELOPMENT CO.
发明人:
GAO, Yu,高宇,BU, Yunli,卜允利
申请号:
CNCN2017/092090
公开号:
WO2018/010594A1
申请日:
2017.07.06
申请国别(地区):
CN
年份:
2018
代理人:
摘要:
A composition comprising a hydroxypropyl methylcellulose, comprising: 1-28 parts by weight of the hydroxypropyl methylcellulose, and 1,000 parts by weight of purified water. The composition further comprises: 1-10 parts by weight of a sodium carboxymethyl cellulose or a maltodextrin, 30-150 parts by weight of a glycerol, 0.3-20 parts by weight of a stabilizer, and 0.001-0.1 parts by weight of a flavoring. The composition further comprises: 1-90 parts by weight of a sodium bicarbonate, 10-40 parts by weight of a xylitol, 0.1-6 parts by weight of a citric acid, 2-9 parts by weight of a potassium hydroxide, 2-10 parts by weight of phosphoric acid, and 0.1-2 parts by weight of a sodium benzoate. The composition further comprises: 10-40 parts by weight of a polydextrose. The hydroxypropyl methylcellulose and a composition comprising same can generate a thin film in the upper gastrointestinal tract, and have a mucoadhesion property.Composition pharmaceutique contenant une cellulose d'hydroxypropyl méthyléther comprenant, exprimées en poids : 1-28 parties de cellulose d'hydroxypropyl méthyléther, 1000 parties d'eau purifiée et comprenant en outre : 1-10 parties de sodium carboxymethylcellulose ou de maltodextrine, 30-150 parties de glycérol, 0,3-20 parties de stabilisateur et 0,001-0,1 partie d'essences. Elle comprend encore : 1-90 parties de bicarbonate de sodium, 10-40 parties de xylitol, 0,1-6 parties d'acide citrique, 2-9 parties d'hydroxide de potassium, 2-10 parties d'acide phosphorique et 0,1-2 parties de benzoate de sodium. Elle comprend par ailleurs 10-40 parties de polydextrose. La cellulose d'hydroxypropyl méthyléther et la composition de protection de la muqueuse gastro-intestinale la contenant sont déposées sur le film de production gastro-intestinal et peuvent y être collées.一种含有羟丙基甲基纤维素的组合物,包括:羟丙基甲基纤维素1~28重量份、纯化水1000重量份;进一步还包括:羧甲基纤维素钠或麦芽糊精1~10重量份、甘油30~150重量份、稳定剂0.3~20重量份、香精0.001~0.1重量份;进一步还包括:碳酸氢钠1~90重量份、木糖醇10~40重量份、柠檬酸0.1~6重量份、氢氧化钾2~9重量份、磷酸2~10重量份、苯甲酸钠0.1~2