KYAS, ANDREAS,FREUND, ERNST,SCHLORKE, OLIVER,PATERNITI, JAMES R.,ELLIOTT, GARY,LILL, JORG,ROGALL, LARS,MENIA, DARIO
申请号：
CA2822694
公开号：
CA2822694A1
申请日:
2011.12.21
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
A cardiogenin major isomer is obtained from a methanol extract of Geum japonicum and separated from its minor isomer. The separation of the two isomers can be achieved by chiral phase chromatography, e.g., using a Chiralpak® IC column. The purity of the isolated cardiogenin major isomer can be further increased by crystallization, yielding isolated cardiogenin major isomer having HPLC purity as high as 98.97% (a/a) at 210 nm and a potency of 95.50%) (w/w).
