KYAS ANDREAS,FREUND ERNST,SCHLÖRKE OLIVER,PATERNITI JAMES R,ELLIOTT GARY,LILL JORG,ROGALL LARS,MENIA DARIO
申请号：
IN1028/MUMNP/2013
公开号：
IN2013MN01028A
申请日:
2013.05.31
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
A cardiogenin major isomer is obtained from a methanol extract of Geum japonicum and separated from its minor isomer. The separation of the two isomers can be achieved by chiral phase chromatography, e.g., using a Chiralpak® IC™ column. The purity of the isolated cardiogenin major isomer can be further increased by crystallization, yielding isolated cardiogenin major isomer having HPLC purity as high as 98.97% (a/a) at 210 nm and a potency of 95.50%) (w/w).
