1. A composition comprising idebenone or a derivative thereof, N-acetyl-S-farnesyl-L-cysteine or a pharmaceutically acceptable salt or ester thereof and ergotionine or a pharmaceutically acceptable salt or ester thereof. 2. The composition according to claim 1, where a) idebenone or its derivative is present in an amount of 0.0001-5.0 weight. % of the total weight of the composition； b) N-acetyl-S-farnesyl-L-cysteine or a pharmaceutically acceptable salt or ester thereof is present in an amount of 0.0001-10.0 weight. % of the total weight of the composition； and c) ergothionein or a pharmaceutically acceptable salt or ester thereof is present in an amount of 0.0001-10.0 weight. % of the total weight of the composition. 3. The composition according to claim 2, where idebenone or its derivative is: .4. A method for preventing skin changes, the method comprising applying the preparation for external use to the skin, the preparation containing an effective amount of idebenone or a derivative thereof, N-acetyl-S-farnesyl-L-cysteine or a pharmaceutically acceptable salt or ester and ergotionine thereof or a pharmaceutically acceptable salt or ester thereof. 5. A method of inhibiting the UV induction of pro-inflammatory cytokines, wherein said method comprises the use of a composition according to claim 1 in relation to an organism where said organism has been exposed to UV radiation. The method according to claim 5, wherein said application occurs by topical application of the composition to the body. The method of claim 6, wherein the composition is applied to an area of the skin of the body. The method of claim 5, wherein the cytokines encompass IL-6 or TNF-α, or a combination thereof. A method of reducing the formation of sunburn of cells, wherein said method involves the use of an effective amount of a composition according to claim 1 in relation to the body, where the specified body has undergone1. Состав, содержащий идебенон или его производное, N-ацетил- S-фарнезил
