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METHOD FOR PRODUCING A DOSING SPRAYING INHALER FOR TREATMENT OF A RESPIRATORY DISEASE
专利权人:
ИНТЕК БИОФАРМ ЛТД
发明人:
Ю Вэй-Сю,ЧАО Ень-Чинь
申请号:
RU2014104996
公开号:
RU2014104996A
申请日:
2012.02.14
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A method of obtaining a composition for a metered-dose inhaler, comprising the steps of: a) mixing alcohol with a surfactant to form a first mixture, the alcohol content being from 0.05% to 10.0% (w / w) of the total the mass of the first mixture; b) adding a beta-2 agonist to the first mixture and dispersing the beta-2 agonist in the first mixture to obtain a second mixture; c) adding a hydrofluoroalkane (HFA) propellant to the second mixture to obtain a third mixture; d) adding a corticosteroid to the third mixture and dispersion of the corticosteroid in tert s mixture; e) filling the third mixture under pressure into a container. 2. A method according to claim 1, wherein said corticosteroid comprises a corticosteroid selected from the group consisting of budesonide, fluticasone, beclomethasone, cyclesonide, fluticasone propionate, beclomethasone dipropionate, and combinations thereof. A method according to claim 1, characterized in that said beta-2 agonist comprises an agonist selected from the group consisting of albuterol, carterol, formoterol, albuterol sulfate, proterol hydrochloride, formoterol fumarate, and combinations thereof. The method according to claim 1, characterized in that the alcohol content is from 0.25% to 2.0% (wt./wt.%). The method of claim 1, wherein said surfactant comprises polyethylene glycol (PEG) having a molecular weight of from 100 to 6000.6. A method according to claim 1, characterized in that the content of the surfactant is from 0.01% to 2.50% (wt./wt.%) Of the total mass. The method of claim 1, wherein said HFA propellant comprises at least one of HFA 134a and HFA 227.8. Composition for metered dose inhaler obtained p1. Способ получения композиции для дозирующего ингалятора, включающий стадии:a) смешивание спирта с поверхностно-активным веществом с получением первой смеси, причем содержание спирта составляет от 0,05% до 10,0% (мас./мас.%) от общей массы первой смеси;b) добавление бета-2-агониста к первой смеси и диспергирование
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