GRICE, CHERYL A.,CISAR, JUSTIN S.,DUNCAN, KATHARINE K.,FENG, YU,WIENER, JOHN J. M.,WEBER, OLIVIA D.
申请号：
ARP180100579
公开号：
AR111271A1
申请日:
2018.03.13
申请国别(地区):
AR
年份:
2019
代理人:
摘要：
Drug compounds and compounds containing these compounds can be used as MAGL and/or FAAH modulators. Compounds and ingredients are now useful in the treatment of pain and neurological disorders. Claim 1: A compound,1. It has the structural characteristics of formula (1)；Among them: A ring was selected from the debris of formula group (5)；Each R1 is selected independently from halogens.- um.C8321833183263； Rent,C8322283318326263； tar；C83218331836263； - OJIL-Or8311；C832183318326； "Halide,C83323833188328； cyclopedia,- No. 8309； No. 8310；- C(O) No. 8309； (R8310,- Or8311；- This is 832222.- SF832525,- 831222,Arilo,And anomalies,Arilo and heterosexuality are replaced by one or two groups independently selected from the halogen.C8321833183263； Rent,C832183318326； "Halide,Y-C(O) NR831223；Two adjacent R1 forms an optional heterosexual ring which is replaced by one or two R1s.R2 is C83218833183268； rent；R3 is selected from halogen.- um.C8321833183263； Rent,C832183318326； "Halide,- No. 8312； No. 8313；- C(O) No. 831222； (R8313)；- No. 831222； (C(O) R8313；Y-NR8313； SO8322； R831222；R3 degree 74919 was selected from halogen.C8321833183263； Rent,C. C83218331 and 83263； halogenated tar；Each R830808 is selected independently from H to C83218331836262； tar；Each R83099 and R8310A is selected independently from H.C8321833183263； Rent,E.C83238331 and 83288 cyclo；O R83099 and R8310；Plus the nitrogen on them.1. Form a selective heterosexuality, replaced by 1-2 R1830404；Each r8311th is selected independently from H.C8321833183263； Rent,C.C832183318326； - O-C832183318326； (Acquilo,C832183318326； "Halide,C83323833188328； cyclopedia,HeterosexualsArilo,And anomalies,There?Arilo,Heterosexuality is replaced by one or two groups independently selected from halogens.C8321833183263； Rent,C. C83218331 and 83263； halogenated tar；Each R831222 and R8313 was independently selected from H.C8321833183263； Rent,C83323833188328； cyclopedia,Arilo,And anomalies,Each r830404 should be selected independently betwee
