Disclosed herein are novel compounds of formula (I), and uses thereof. The compounds of Formula (I) are inhibitors of histone deacetylases (HDACs) and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (HMGR). Also provided are methods of using the compounds of Formula (I) for inhibiting the activity of HDACs and HMGR, treating diseases associated with HDACs or HMGR (e.g., cancer, hypercholesterolemia, an acute or chronic inflammatory disease, autoimmune disease, allergic disease, pathogen infection, neurodegenerative disease, or a disease associated with oxidative stress).本揭示內容是有關於如式(I)之新穎化合物及其用途。式(I)之化合物為組蛋白去乙醯酶及3-羥-3-甲基戊二輔酶A還原酶之抑制劑。本揭示內容亦提供一種方法,其係利用如式(I)之化合物來抑制組蛋白去乙醯酶及3-羥-3-甲基戊二輔酶A還原酶,且用以治療組蛋白去乙醯酶或3-羥-3-甲基戊二輔酶A還原酶之相關疾病(例如,癌症、高膽固醇血症、急性或慢性發炎疾病、自體免疫疾病、過敏疾病、病原體感染、神經退化疾病或與氧化壓力相關之疾病)。
